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Fasting levels of blood glucose (n = 8 each group) (m) and insulin (n = 6 WT, n = 7 KO) (n) in 54-week old female WT and KO mice, as well as fasting plasma levels of triglycerides (n = 6 WT, n = 7 KO) (o) and cholesterol (n = 6 WT, n = 7 KO) (p) in 55-week old female WT and KO mice

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Additionally, there was variation in the quality of included studies as the risk of bias, methodological rigor, and data integrity were not well tracked or standardized across the available articles

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One study examined treatment periods that lasted more than 36 weeks