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A randomized controlled trial (RCT) demonstrated that after 6 months of supplementation with 1.2 g/d of EPA + DHA for patients with knee OA, the WOMAC pain score decreased by 23% ( p = 0.02), and the synovial inflammation assessed by MRI was relieved (42)

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Enhanced IL-8 expression production of both normal human keratinocytes and HaCaT cells was observed after stimulation in vitro by both irritants, sensitizer and tolerogen

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These techniques can be particularly valuable for athletes with compromised healing due to previous injuries or other factors