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Gastrointestinal Side Effects Nausea is the most commonly reported adverse effect across GLP-1 trials, occurring in 44% of semaglutide-treated patients versus 16% with placebo in STEP-1

The higher-concentration versions cost more to produce because raw ingredient costs scale with potency, and 503B compounding facilities must verify potency through third-party lab testing

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Additionally, semaglutide may interact with certain diabetes medications (particularly sulfonylureas), potentially increasing low blood sugar risk