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The SURPASS-CVOT trial, evaluating cardiovascular outcomes with tirzepatide, is ongoing

T2D is commonly associated with relevant clinical conditions that are implicated in worse prognosis, increased mortality, and negative impacts on patient health-related quality of life, such as obesity and cardiovascular disease (CVD) [4]

reported a decreased mucus thickness in the colon of cirrhotic patients and a breakdown of E-cadherin and occludin by endogenous and newly identified bacterial proteases respectively, which could be future therapeutic targets (151)

However, semaglutide offers distinct advantages in specific clinical contexts

A comparison with hGH and a review of its regulatory status provide a clearer picture of its overall safety

Fry CS, Rasmussen BB