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On the other hand, it is interesting to outline how the G6PD deficiency (variant A-) is associated with an increase in the resistance to the infection caused by Plasmodium falciparum in the sub-Sahara region of Africa

In the SURMOUNT-1 and -3 studies, tirzepatide administered at a high dose of 15 mg subcutaneously once weekly resulted in approximately a 20% reduction in body weight in overweight and obese, non-diabetic adults, even after up to 2 years of treatment [84,85]

While standard therapeutic doses have demonstrated cardiovascular and metabolic benefits in large clinical trials, the concept of using low dose GLP-1 for inflammation remains investigational, with no established FDA indication or standardized dosing protocols