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The age-related decline in melatonin and dampening of circadian rhythms likely contributes to sleep problems, metabolic and cognitive decline, and increased vulnerability to age-related diseases

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Bariatric surgery for qualified individuals is the next option if lifestyle changes and pharmacotherapy are unable to meet individualized weight loss goals [132]

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Key facts Blue Cross Blue Shield of Massachusetts ended weight-loss GLP-1 coverage effective January 1, 2026 a regional signal of cost pressure that Harvard Pilgrim members in New England should factor into their coverage verification