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Histopathological parameters assessed included neutrophil numbers and neovascularization
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Within each active month, the 5-days-on, 2-days-off schedule follows the same logic at the weekly level: it prevents tachyphylaxis (diminished response from constant exposure) while maintaining enough stimulus frequency to produce measurable visceral fat reduction
Arginelli F, Greco M, Ciardo S, et al
Consistent with the distribution of Firmicutes in the cecal samples, the relative abundance of Ileibacterium was highest in the WD controls (average relative abundance 68%), second highest in the LD controls (average relative abundance 51%), and lowest in the vehicle- and 5A-1MQ-treated mice switched from WD to LD (average relative abundances of 40% and 41%, respectively)