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For L-Carnitine specifically, taking it 30-60 minutes before exercise gives carnitine time to reach working muscle tissue at elevated concentrations during the training window

Plant Physiol 124:13811392 Mullineaux PM, Rausch T (2005) Glutathione, photosynthesis and the redox regulation of stress-responsive gene expression

Contacted by NPR for comment, Novo Nordisk spokeswoman Liz Skrbkova said in an email the study misrepresents the company's "paid search approach," which she says uses "industry-standard" capabilities to reach consumers

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Normally, Nrf2 is associated with a group of proteins, including cytoplasmic Kelch-like ECH-associated protein1 (Keap1) and Cul3 (Cullin3), and is localized in the cytoplasm