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The main concern is that GLP-1 medications slow stomach emptying, which can slightly delay metformin absorption, but this rarely causes clinical problems
Low-grade inflammation (median hsCRP approximately 4.1 g/mL) and immune activation markers were common, underscoring the clinical relevance of slowing biological aging in this setting
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Key findings included: Excellent tolerability with less than 10% reporting any digestive discomfort Dose-dependent biological responses indicating successful butyrate generation Favorable shifts in markers such as hs-CRP Metabolic effects suggesting enhanced butyrate availability Confirmation that 200mg daily appears to be the optimal dose The ButyraGen Clinical Breakthrough (Dosz 2025) The second study focused on individuals seeking digestive comfort, providing even more compelling results
