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doi: 10.1371/journal.pone.0193473 69 WangX.LiZ.HuangX.LiF.LiuJ.LiZ.et al

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Nasal delivery of nerve growth factor rescue hypogonadism by up-regulating GnRH and testosterone in aging male mice

Declining AMPK activity, accumulating visceral adiposity, deteriorating insulin sensitivity, weakening thermogenic capacity, reduced exercise-mimetic signaling, and dysregulated appetite hormones are separate but interconnected processes

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