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On the other hand, when women with obesity and lipedema lose more substantial weight through medical or surgical interventions, they can lose some fat from the areas with lipedema, which can then leave them with rolls of excess skin along in the areas of remaining lipedema fat tissue (Figure 4)

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Xu X, Liu S, Liu H, Ru K, Jia Y, Wu Z, et al

Nevertheless, they represent a great advance in investigation technology and their attempt to biomimicking cell and tissue environment is a crucial advantage compared to 2D cultures and a promising complement to animal model studies with great potential for further investigation of ECD in the context of CVDs