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To evaluate the effect of miRNA-200b/c in vivo , Tg2576 mice were treated with miRNA-200b/c by intracerebroventricular injection

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333 It is reported that LRRK2 G2019S dopaminergic neurons exhibit a decreased NAD + pool and a reduced sirtuin deacetylase activity, correlating with elevated acetylation of sirtuin substrates p53, -tubulin and SOD2

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