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Although the intraperitoneal administration of exendin 939 did not cause adverse hyperthermia effects, a critical aspect of developing TRPV1 antagonists is minimizing interference with TRPV1 activation by protons and hence identifying mode-selective antagonists 32

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GLP-1 agonists in pediatric obesity: an integrative perspective on cell signaling, development, and metabolism

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J Pharmacol Exp Ther 369(1):129141

Someone titrating slowly (starting at 1 mg, increasing by 1-2 mg every four weeks) will see a slower onset than someone who starts at 2 mg and increases by 2 mg every two weeks