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doi: 10.1038/ng.863 148 ZiadaASLuMYIgnas-MenziesJPaintsilELiMOgbuaguOet al

Lebedov J, Hedberg YS, Odnevall Wallinder I, Karlsson HL

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For instance, upregulating GPX4 in ferroptosis-sensitive chondrocytes, restoring antioxidant defenses in inflammatory synovial macrophages, or rebalancing iron export in subchondral osteoblasts may prevent tissue-specific degeneration