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I-BET151 (a selective inhibitor of BET) can reduce joint inflammation and bone loss by blocking MMP-1, MMP-3, IL-6, and IL-8 production in RA FLS (190, 306)

| 05.13.26 | 11 min read

Most side effects are reversible upon discontinuation of therapy, but serious reactions necessitate prompt evaluation and supportive care

One recent study used CRISPRa to successfully restore neuronal excitability and electrophysiological deficits in Scn2a +/- mice to wild-type levels, an effect that persisted until at least 3 and 8 months, respectively [78]