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Should metformin dose be increased first in a patient with type 2 diabetes mellitus, HbA1c 5.8%, taking metformin 500 mg daily, phentermine, and NP thyroid 60 mg daily, with poor diet and exercise compliance, before considering GLP-1 receptor agonists?

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This study provides us with a potential therapeutic target while reminding us that the mechanism of neurotoxicity may not be the same between NHPs and rodents

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10.1007/s10072-019-04150-5 Neurol