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doi: 10.1016/j.eclinm.2024.102475 20 MozaffarianD
Quick Answer: GLP-1 medications originated from exendin-4, a peptide discovered in Gila monster venom that mimics human GLP-1 hormone with enhanced stability, leading to FDA-approved diabetes treatments
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The two peptides operate on entirely separate biological pathways: sermorelin targets the hypothalamic-pituitary-GH axis, while tirzepatide targets incretin receptors in the gut and brain
All testing solutions were prepared by diluting stock solution with DMSO and PBS/imaging buffer/culture medium
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