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In a Phase 2 obesity trial of retatrutide published in the New England Journal of Medicine in 2023, nausea, diarrhea, vomiting and constipation were cited as the most common adverse events, with higher doses associated with more severe problems

Fasting C-peptide levels increased while the Homeostatic Model Assessment for Insulin Resistance (HOMA IR) decreased

Obesity itself seldom qualifies unless fat removal directly addresses a particular complication, such as massive localized lymphedema leading to recurrent cellulitis

2014, 307 (4): H477-H492

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If the diet becomes more limited (for example skipping meals, eating less food), one may inadvertently reduce intake of whole-food nutrient variety