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For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

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Finally, SELECTs unambiguous message that weight management saves lives makes a compelling case, and creates an ethical imperative, for payers and policy makers to expand coverage, including revisiting the statutes prohibiting Medicare from covering anti-obesity drugs