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Tau dephosphorylation and microfilaments disruption are upstream events of the anti-proliferative effects of DADS in SH-SY5Y cells

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doi: 10.14670/HH-17.707

76 GST prodrugs appear to have a more favorable adverse-event profile, given that they are ingested as an inactive compound and undergo breakdown to release cytotoxic metabolites only in the presence of high concentrations of enzymes that occur in the proximity of tumor cells, thereby reducing collateral damage to healthy cells

Okamoto, I., Miyatake, Y., Kimoto, M

A pesar de que los niveles de hipoxia con el ERFS son realmente moderados, se postula que se podra llegar a comprometer la excitabilidad neuromuscular, con lo cual se generara cierta fatiga tanto central como perifrica