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N Engl J Med 377:11191131

The Contraindication Is About Cancer, Not Hormone Levels Wegovy carries a boxed warning stating that in rodents, semaglutide causes thyroid C-cell tumors at clinically relevant exposures, and that whether it causes thyroid C-cell tumors including medullary thyroid carcinoma in humans has not been determined

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Studies have shown that patients who stop the medications often regain the weight

Body Weight Changes Animals in the control group had a consistent increase in body weight with values at day 21 (166 12.1g) being 19.4% higher than initial body weights (139 6.4g) (Table 1)