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Predictive biomarkers, particularly those linked to key regulatory axes such as NRF2/p62, COX7A1 or USP13, require urgent discovery and clinical validation to reliably predict sensitivity to ferroptosis inducers or autophagy modulators

TGF-beta-1 is elevated in balding scalp tissue and contributes to follicle regression

Individual results vary based on starting weight, dose maintenance, dietary changes, exercise, and program adherence

In the SURMOUNT-1 trial, 95 percent of participants taking tirzepatide reverted to normal blood sugar over 176 weeks, and 99 percent stayed diabetes-free

Hence, fragment library design or selection plays a foundational role in FBDD by ensuring that screened compounds are diverse, synthetically tractable, and optimised for downstream progression 16