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Subsequently, we applied a focused refinement approach on the particles used in the reconstruction of holo-complex to improve the resolution for c-MET I and HGF I, resulting in a new cryo-EM map with resolution improved to 4.5 , which allowed us to build reliable models for the K3 and K4 domains of HGF (Supplementary Figs
The fixed-ratio nature of the blend also means components cannot be titrated independently: any adjustment scales all four peptides together
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182 [31.5%]), 10% or more (838 [69.1%] vs
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