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The FIDELITY pooled analysis ( n = 13,026) integrated data from both trials, confirming consistent cardiorenal benefits: a 23% reduction in the composite kidney outcome (HR 0.77

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More in hormones HRT Black Box Warning Removed: What the FDA's 2025 Decision Means The FDA moved to revise the HRT black box warning in 2025

The earlier 12-week Phase 2a trial had shown encouraging results (2.6 kg vs 0.8 kg for placebo), but the larger, longer, better-powered trial reversed that finding

Dietary intake of heme iron and risk of cardiovascular disease: a dose-response meta-analysis of prospective cohort studies

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