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Step 1: Identify the Primary Clinical Problem Start with the actual medical objective

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The ongoing Yoga-EndOmics trial is designed to examine how yoga-based cardiac rehabilitation influences endothelial function, arterial stiffness, and redox-relevant genomic pathways in heart failure, reflecting growing recognition that integrative movement modalities may support mitochondrial and vascular health through coordinated metabolic and neurohumoral mechanisms (27)

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