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19 , 5809.e5 (2021)

Lancet (2016) 388(10053):1659724

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Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]

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17 Recent advances in pharmacological treatments Sodium-glucose cotransporter-2 inhibitors SGLT-2 inhibitors (empagliflozin and dapagliflozin) are recommended in most people with type 2 diabetes and CKD, given the strong evidence that SGLT-2 inhibitors reduce CKD progression, heart failure and the risk of atherosclerotic CV disease in people with type 2 diabetes and CKD