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References 1 MaoJPopVJBathSCVaderHLRedmanCWRaymanMP

How it affects pigmentation: Melanin synthesis (melanogenesis) is controlled by enzymes like tyrosinase

Viruses 11 , 59 (2019)

In some embodiments, the ratio of a thermoreversible poloxamer to a thickening agent in a formulation that has a pH as described herein is about 40:1, about 35:1, about 30:1, about 25:1, about 20:1, about 15:1, about 10:1, or about 5:1

However, its important to note that these numbers can be (and often are) increased if FDA requires a written response or additional information from the manufacturer

R., Ellison, A