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In contrast, GSH depletion drives M1 polarization, resulting in heightened secretion of pro-inflammatory cytokines, including TNF-, IL-6, and IL-1 ( Overall, GSH helps limit unwanted immune attacks in the brain

Inhibition of the Xc-system determines the decrease in GSH levels, which indirectly leads to the inactivation of GPX4 and the onset of ferroptosis (Ursini and Maiorino, 2020)

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