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The Phase 2 trial reference point The Phase 2 retatrutide trial (Jastreboff et al., New England Journal of Medicine 2023) enrolled 338 adults across placebo and retatrutide arms at 1, 4, 8, and 12 mg weekly

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Precision: Use smaller syringes (e.g., 30-unit or 50-unit) for more accurate, smaller doses

23 The SURMOUNT-1 trial revealed a mean percent change in BW over placebo of 15%, 19.5% and 20.9% in those receiving tirzepatide at doses of 5, 10, and 15 mg, respectively

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However, the intensity of this need varies considerably depending on age and life circumstances