Prins, PhD, the Michael Reese Endowed Professor in the Departments of Urology, Physiology and Biophysics, and Pathology at the University of Illinois at Chicago (UIC) as well as co-director of the Prostate Cancer Research Program at the UIC Cancer Center reviewed several top candidate papers, settling on two from her journal
Regional susceptibility to stress-induced intestinal injury in the mouse
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utilized mouse models with selective elimination of proglucagon expression in the distal gut versus the entire gut and found that gut-derived GLP-1 is the predominant source of increased circulating GLP-1 following nutrient ingestion, slows gut motility, and contributes to maintenance of oral glucose tolerance, but does not contribute to insulin secretion (40)
