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in these cases, mildly elevated TSH values (up to 67.5 mU/L) may not reflect true hypothyroidism and do not necessarily require intervention, particularly in the absence of symptoms

Int J Rheum Dis 2014: 15

Mechanistic evidence from animal models requires validation in human interventional studies before therapeutic targeting can be recommended

Timeline to Expect: During the first 8 weeks: Many patients notice decreases in appetite and increases in energy levels

That does not make one universally better

Begin with a single compound, learn how your body responds, and only consider combination therapy after establishing that foundation