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J Am Soc Nephrol 2010;21:527-35.ArticlePubMedPMC 13

This participant was already taking tirzepatide when she enrolled in the trial, but before any stimulation was delivered, giving us a unique opportunity to make foundational observations about how the drug alters brain signals. At first, results were promising: As patient 3s tirzepatide levels reached full dosage, craving-linked NAc activity in her brain went dormant and she had no obsessive thoughts about food

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