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Retatrutide represents the current pinnacle of this "modular" metabolic engineering, but its utility must be measured against the established benchmarks of dual-agonists

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Moreover, there was no significant difference in weight loss between tirzepatide 15 mg and one-anastomosis gastric bypass [median difference (MD)] = 2.97%: 95% CI, 3.85 to 9.79) or between tirzepatide 15 mg and laparoscopic sleeve gastrectomy (MD = 0.43%

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Manganese absorption depends on dietary intake and occurs in the small intestine