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The STEP 5 trial demonstrated that continued treatment for 104 weeks maintained weight loss, while the STEP 1 extension study showed that discontinuing semaglutide at 68 weeks led to two-thirds of the weight lost being regained within a year

doi: 10.1196/annals.1338.067 44 VincentAMPerroneLSullivanKABackusCSastryAMLastoskieCet al

Mistake 5: Ignoring hormonal signals Missed periods, significant cycle irregularity, or symptoms of estrogen deficiency during rapid weight loss should be communicated to a healthcare provider