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Metformin, commonly used in diabetes management, has been associated with reduced vitamin B12 absorption, potentially through effects on calcium-dependent vitamin B12-intrinsic factor absorption in the terminal ileum

Top image credit: Mike Blyth Hand, foot, and mouth disease KlatschmohnAcker / Wikimedia Commons What it looks like : Hand, foot, and mouth disease is named for its characteristic flat, red spots that appear on the palms, soles of the feet, and around the mouth

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Informed consent In clinical trials, informed consent is critical

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