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259 SIRT4 functions as an ADP-ribosyltransferase, promoting tumorigenicity when induced under oncogenic stress 260 and maintaining metabolic homeostasis

Preventing this decrease, with the administration of a SIRT-1 activator, reversed ROS bursts, increased downstream nuclear PGC-1a and Nrf2 expression, and attenuated increases in mitochondrial membrane potential and neuronal apoptosis induced by ischemia/reperfusion injury [78]

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