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This albumin binding dramatically extends the peptides half-life from minutes to approximately 68 days, enabling once-weekly dosing [2]

Disclaimer: Comprehensive human safety data for these peptides are limited

J Biol Chem 2002;277:4379943808

Age represents one clear response modifier, with some evidence suggesting greater absolute improvements in older patients with more pronounced baseline deficits in matrix density and collagen content

This is the conservative recommendation based on preservative effectiveness and peptide stability data