semaglutide efficacy and safety of oral monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes (PIONEER 11): a double-blind, Phase IIIa, randomised trial Semaglutide's Efficacy in Phase 3

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doi: 10.1001/jamanetworkopen.2020.19722 42 MessikaJ.SztrymfB.BertrandF.Billard-PomaresT.BarnaudG.BrangerC.et al

Glossary AAPH 2,2'-Azobis(2-amidinopropane) dihydrochloride AD Alzheimers Disease ALA Alpha-Lipoic Acid AMPK/SIRT1 AMP-activated protein kinase/Sirtuin 1 AUC Area Under the Curve BChE Butyrylcholinesterase CAT Catalase CGA Chlorogenic acid CoQ10 Coenzyme Q10 COPD Chronic Obstructive Pulmonary Disease CVD Cardiovascular Disease CUPRAC cupric reducing antioxidant capacity DPPH 2,2-diphenyl-1-picrylhydrazyl EGCG Epigallocatechin gallate (corrected from ECG) EGFR Epidermal Growth Factor Receptor EOs Essential Oils ETC Electron Transport Chain FRAP ferric reducing antioxidant power GLUT4 Glucose transporter 4 GSH-Px Glutathione peroxidase H 2 O 2 Hydrogen peroxide HDL High-Density Lipoprotein HNC Head and Neck Cancer HS-GC Headspace Gas Chromatography KMBA -Keto--methylthiobutyric acid LDL Low-Density Lipoprotein MnSOD Manganese-dependent Superoxide Dismutase MS Multiple Sclerosis MT Melatonin NF-B Nuclear factor kappa B NO Nitric oxide NOX NADPH oxidase O 2 Superoxide anion ONOO Peroxynitrite ORAC oxygen radical absorbance capacity OS oxidative stress PCOS Polycystic Ovary Syndrome PCL Photochemiluminescence PDX-1 Pancreaticoduodenal homeobox factor 1 Prx Peroxiredoxin ROS Reactive Oxygen Species RTT Rett Syndrome SOD Superoxide dismutase TEAC Trolox-Equivalent Antioxidant Capacity TOSC total oxidant scavenging capacity TRAP total radical-trapping antioxidant Parameter Trx Thioredoxin T2D Type 2 Diabetes Mellitus VEGF Vascular Endothelial Growth Factor VPA Valproic acid OH hydroxyl radical References 1 AddoP

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5-amino-1MQ addresses the cellular metabolic inefficiency that prevents stored fat from being mobilized and oxidized

several blood and immune system diseases