Composite cardiovascular events were defined as the first occurrence of unstable angina, myocardial infarction, revascularization (i.e., including PCI, coronary artery bypass, and stenting)
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It should be noted that the extent of weight loss achieved with GLP-1RA add-on to SGLT2i appears anyway modest compared to the efficacy of newer treatments for weight management, including dual incretin receptor agonists
In December 2025, the FDA approved the first oral GLP-1 formulation for weight management an oral version of Wegovy giving patients an alternative to injections