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Given its unique dual role as an anti-ferroptosis and pro-necroptosis agent, regulating the expression and subcellular localization of FSP1 in different pathological states represents a key step toward developing effective prognostic and treatment strategies for related diseases

For assessing GPX4 expression, we used samples derived from female C57BL/6J (Charles River Laboratories UK, RRID: IMSR_JAX:000664) mice transduced at 56 weeks of age

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Glutathione can help to neutralise free radicals and toxins preventing their build up which can lead to cellular damage and oxidative stress

Last reviewed: July 26, 2026 by Peerless Research