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While this approach may create complications in terms of attributing any demonstrated cognitive effects, assessment of the nutritional status at baseline and after supplementation will presumably help inform mechanistic questions

GSH is the primary endogenous antioxidant depleted in PD and NAC promote glutathione homeostasis indirectly by providing cysteine for GSH synthesis

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The effectiveness of glutathione suppositories can vary based on individual patient factors and the specific disease state being treated

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