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This efficacy differential highlights an important trade-off in the oral GLP-1 space: orforglipron offers the convenience of oral administration and freedom from injection but, based on current data, produces somewhat less weight loss than the most potent injectable multi-receptor agonists

The wrinkle (no pun intended) is that levels crash as we get older

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(2023) A biocatalytic platform for asymmetric alkylation of -keto acids by mining and engineering of methyltransferases, Nat

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