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Proc Soc Exp Biol Med (1999) 222:5964

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DNA methylation is one of the most significant epigenetic modifications associated with depression, and DNA methyltransferase (DNMT) is a key enzyme involved in this process

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The peptides may have potential roles as adjunctive therapies or alternative treatments for patients who cannot tolerate or do not respond adequately to conventional treatments, but this should be based on careful risk-benefit analysis and appropriate patient selection