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Tirzepatide was the first dual GLP-1/GIP agonist to reach approval, and the published SURMOUNT-1 trial showed that adding GIP to GLP-1 produces additive metabolic effects

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It has a 94% structural similarity to glucagon-like peptide (GLP)-1 and binds the GLP-1 receptor with an affinity of 0.38 nM

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