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Similar results have been described for the treatment of non-small-cell lung cancer (NSCLC) [16], breast cancer [31, 42], ovarian cancer [31, 43, 44], hepatocellular carcinoma [45, 46], malignant mesothelioma [47, 48], thyroid cancer [49, 50], oral squamous cell carcinoma [51], neuroblastoma [52] and glioma, including the difficult-to-treat glioblastoma multiform (GBM) [16, 53, 54]

There is an urgent unmet need to develop novel therapeutic approaches to enhance the tumour response to neoCRT to offer improved treatment and survival rates for rectal cancer patients

Nausea or transient gastrointestinal discomfort during initial dosing

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