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Pycnogenol s favorable impact on blood circulation was demonstrated in multiple ways, like the improvement of endothelial function or microcirculation in clinical RDP trials on cardiovascular health, chronic venous insufficiency, on skin and hair health, eye health and menopause (9, 11, 12, 2022, 2833, 4347)

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It is not clear whether the long-term use of H 2 -receptor antagonists could cause overt vitamin B 12 deficiency (141, 142)

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