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H.PothoulakisC.LaMontJ

Semaglutide Improves Cardiovascular Outcomes in Patients With History of Coronary Artery Bypass Graft and Obesity

Long-term cardiovascular outcome data from the SELECT trial showed that semaglutide reduced major adverse cardiovascular events by 20% compared to placebo indicating net cardiovascular protection, not harm

Although many mediators are involved in this process, the most important is hyperglycemia itself as well as the generation of advanced glycosylation end products that may trigger reactive oxygen species (ROS) production and mitochondrial dysfunction

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However, the reactions in both matrices obeyed pseudo-first-order kinetics