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Consequently, a deficiency in the M subunit due to mutations in the PFKM gene causes myopathy and a mild hemolytic disorder (Tarui disease or glycogen storage disease VII, OMIM 610681)

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However, as oral options become more widely used, comfort with prescribing them is increasing

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In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions