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For example, hyperglycemia increases the O-GlcNAc modification of calcium/calmodulin-dependent protein kinase II (CaMKII), which in turn leads to the autonomous activation of CaMKII (51, 52)

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Apart from other genes, glutathione S-transferase Mu class gene (GSTM1) from the human genome has been edited using CRISPR-Cas9 system (Sanjana et al., 2014)

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