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3.3.1 Central immune system: aberrant activation of microglia and astrocytes In EDC, aberrant microglial and astrocytic activation constitutes a central mechanism linking neuroinflammation to neural circuit dysfunction

The disorder is characterized by seven biochemically distinct alterations, all resulting in the increase in concentrations of homocystine and methionine in body fluids (Table 1)

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Hansson J, Berhane K, Castro VM, Jungnelius U, Mannervik B, Ringborg U: Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid